Molecular Dynamics Imaging Unit - Publication

Molecular Dynamics Imaging Unit

Exploration of Antiemetics for Osteoporosis Therapy-Induced Nausea and Vomiting Using PET Molecular Imaging Analysis to Gastrointestinal Pharmacokinetics

Shingaki T, Katayama Y, Nakaoka T, Takashima T, Onoe K, Okauchi T, Hayashinaka E, Wada Y, Cui Y, Watanabe Y.
Pharm Res., 33(5), 1235-1248 (2016).

Extension of recovery time from fatigue by repeated rest with short-term sleep during continuous fatigue load: Development of chronic fatigue model

Kanzaki A, Okauchi T, Hu D, Shingaki T, Katayama Y, Koyama H, Watanabe Y, Cui Y.
J Neurosci Res, 94(5), 424-429 (2016).

Visualization of drug translocation in the nasal cavity and pharmacokinetic analysis on nasal drug absorption using positron emission tomography in the rat

Shingaki T, Katayama Y, Nakaoka T, Irie S, Onoe K, Okauchi T, Hayashinaka E, Yamaguchi M, Tanki N, Ose T, Hayashi T, Wada Y, Furubayashi T, Cui Y, Sakane T, Watanabe Y
Eur J Pharm Biopharm.,(99), 45-53 (2015).

A voxel-based analysis of brain activity in high-order trigeminal pathway in the rat induced by cortical spreading depression.

Cui YL, Toyoda H, Sako T, Onoe K, Hayashinaka E, Wada Y, Yokoyama C, Onoe H, Kataoka Y, Watanabe Y.
Neuroimage, 108, 17-22 (2015).

Quantitative evaluation of mMate1 function based on minimally invasive measurement of tissue concentration using PET with [¹¹C]Metformin in mouse.

Shingaki T, Hume WE, Takashima T, Katayama Y, Okauchi T, Hayashinaka E, Wada Y, Cui Y, Kusuhara H, Sugiyama Y, Watanabe Y.
Pharm Res, in press, (2015).

Cytoarchitecture-Dependent Decrease in Propagation Velocity of Cortical Spreading Depression in the Rat Insular Cortex Revealed by Optical Imaging

Fujita S, Mizoguchi N, Aoki R, Cui YL, Koshikawa N, Kobayashi M.
Cereb Cortex, in press, (2015).

Role of cortical spreading depression in the pathophysiology of migraine

Cui YL, Kataoka Y, Watanabe Y.
Neurosci Bull, 30(5), 812-822 (2014).

Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with F-18-incorporated oligodeoxynucleotides

Mukai H, Ozaki D, Cui Y, Kuboyama T, Yamato-Nagata H, Onoe K, Takahashi M, Wada Y, Imanishi T, Kodama T, Obika S, Suzuki M, Doi H, Watanabe Y.
J Control Release, 180, 92-99 (2014).

The synthesis and biodistribution of [C-11]metformin as a PET probe to study hepatobiliary transport mediated by the multi-drug and toxin extrusion transporter 1 (MATE1) in vivo

Hume WE, Shingaki T, Takashima T, Hashizume Y, Okauchi T, Katayama Y, Hayashinaka E, Wada Y, Kusuhara H, Sugiyama Y, Watanabe Y.
Bioorg Med Chem, 21(24), 7584-7590 (2013).

Positron emission tomography study on pancreatic somatostatin receptors in normal and diabetic rats with Ga-68-DOTA-octreotide: A potential PET tracer for beta cell mass measurement

Sako T, Hasegawa K, Nishimura M, Kanayama Y, Wada Y, Hayashinaka E, Cui YL, Kataoka Y, Senda M, Watanabe Y.
Biochem Biophys Res Commun, 442(1-2), 79-84 (2013).

Evaluation of Oatp and Mrp2 Activities in Hepatobiliary Excretion Using Newly Developed Positron Emission Tomography Tracer [C-11]Dehydropravastatin in Rats

Shingaki T, Takashima T, Ijuin R, Zhang X, Onoue T, Katayama Y, Okauchi T, Hayashinaka E, Cui YL, Wada Y, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
J Pharmacol Exp Ther, 347(1), 193-202 (2013).

Functional neuroimaging of aversive taste-related areas in the alert rat revealed by positron emission tomography

Kobayashi M, Cui YL, Sako T, Sasabe T, Mizoguchi N, Yamamoto K, Wada Y, Kataoka Y, Koshikawa N.
J Neurosci Res, 91(10), 1363-1370 (2013).

Synthesis of an ¹¹C-Labeled Antiprion GN8 Derivative and Evaluation of Its Brain Uptake by Positron Emission Tomography

Kimura T, Sako T, Siqin, Hosokawa-Muto J, Cui YL, Wada Y, Kataoka Y, Doi H, Sakaguchi S, Suzuki M, Watanabe Y, Kuwata K.
ChemMedChem, 8(7), 1035-1039 (2013).

Apomorphine-induced modulation of neural activities in the ventrolateral striatum of rats

Fujita S, Kato R, Cui YL, Terakado M, Suga K, Koshikawa N, Kobayashi M.
Synapse, 67(7), 363-373 (2013).

Dynamic analysis of fluid distribution in the gastrointestinal tract in rats: positron emission tomography imaging after oral administration of nonabsorbable marker, [(18)F]Deoxyfluoropoly(ethylene glycol).

Takashima T, Shingaki T, Katayama Y, Hayashinaka E, Wada Y, Kataoka M, Ozaki D, Doi H, Suzuki M, Ishida S, Hatanaka K, Sugiyama Y, Akai S, Oku N, Yamashita S, Watanabe Y
Mol Pharm, 10(6), 2261-2269 (2013).

Chronic degeneration of dorsal raphe serotonergic neurons modulates cortical spreading depression: A possible pathophysiology of migraine

Cui YL, Li QH, Yamada H, Watanabe Y, Kataoka Y.
J Neurosci Res, 91(6), 737-744 (2013).

Dynamic analysis of GI absorption and hepatic distribution processes of telmisartan in rats using positron emission tomography.

Kataoka M, Takashima T, Shingaki T, Hashidzume Y, Katayama Y, Wada Y, Oh H, Masaoka Y, Sakuma S, Sugiyama Y, Yamashita S, Watanabe Y.
Pharm Res, 29(9), 2419-2431 (2012).

PET imaging-based evaluation of hepatobiliary transport in humans with 15R-¹¹C-TIC-Me.

Takashima T, Kitamura S, Wada Y, Tanaka M, Shigihara Y, Ishii H, Ijuin R, Shiomi S, Nakae T, Watanabe Y, Cui Y, Doi H, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
J Nucl Med, 53(5), 741-748 (2012).

Imaging of gastrointestinal absorption and biodistribution of an orally administered probe using positron emission tomography in humans.

Shingaki T, Takashima T, Wada Y, Tanaka M, Kataoka M, Ishii A, Shigihara Y, Sugiyama Y, Yamashita S, Watanabe Y.
Clin Pharmacol Ther, 91(4), 653-659 (2012).

PET of aromatase in gastric parietal cells using ¹¹C-vorozole.

Ozawa M, Takahashi K, Akazawa KH, Takashima T, Nagata H, Doi H, Hosoya T, Wada Y, Cui Y, Kataoka Y, Watanabe Y.
J Nucl Med, 52(12), 1964-1969 (2011).

PET imaging of the gastrointestinal absorption of orally administered drugs in conscious and anesthetized rats.

Yamashita S, Takashima T, Kataoka M, Oh H, Sakuma S, Takahashi M, Suzuki N, Hayashinaka E, Wada Y, Cui Y, Watanabe Y.
J Nucl Med, 52(2), 249-256 (2011).

Stoichiometry-focused ¹⁸F-labeling of alkyne-substituted oligodeoxynucleotides using azido([¹⁸F]fluoromethyl)benzenes by Cu-catalyzed Huisgen reaction.

Kuboyama T, Nakahara M, Yoshino M, Cui Y, Sako T, Wada Y, Imanishi T, Obika S, Watanabe Y, Suzuki M, Doi H.
Bioorg Med Chem, 19(1), 249-255 (2011).

Positron emission tomography studies using (15R)-16-m-[¹¹C]tolyl-17,18,19,20-tetranorisocarbacyclin methyl ester for the evaluation of hepatobiliary transport.

Takashima T, Nagata H, Nakae T, Cui YL, Wada Y, Kitamura S, Doi H, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
J Pharmacol Exp Ther, 335(2), 314-323 (2010).

Mapping of regional brain activation in response to fatigue-load and recovery in rats with c-Fos immunohistochemistry.

Akazawa KH, Cui YL, Tanaka M, Kataoka Y, Yoneda Y, Watanabe Y.
Neurosci Res, 66(4), 372-379 (2010).

¹¹C-PK11195 PET for the in vivo evaluation of neuroinflammation in the rat brain after cortical spreading depression.

Cui YL, Takashima T, Takashima-Hirano M, Wada Y, Shukuri M, Tamura Y, Doi H, Onoe H, Kataoka Y, Watanabe Y.
J Nucl Med, 50(11), 1904-1911 (2009).

Up-regulated neuronal COX-2 expression after cortical spreading depression is involved in non-REM sleep induction in rats.

Cui YL, Kataoka Y, Inui T, Mochizuki T, Onoe H, Matsumura K, Urade Y, Yamada H, Watanabe Y.
J Neurosci Res, 86(4), 929-936 (2008).

Neuroprotection by a central nervous system-type prostacyclin receptor ligand demonstrated in monkeys subjected to middle cerebral artery occlusion and reperfusion: a positron emission tomography study.

Cui YL, Takamatsu H, Kakiuchi T, Ohba H, Kataoka Y, Yokoyama C, Onoe H, Watanabe Y, Hosoya T, Suzuki M, Noyori R, Tsukada H, Watanabe Y.
Stroke, 37(11), 2830-2836 (2006).

Intrapancreatic axonal hyperbranching of dorsal root ganglia neurons in chronic pancreatitis model rats and its relation to pancreatic pain.

Takamido S, Kataoka Y, Tanano A, Cui Y, Ikeura T, Shimatani M, Kubota Y, Okazaki K, Yamada H.
Pancreas, 33(3), 268-279 (2006).

Molecular Dynamics Imaging Unit

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