Labs & Technologies

Chemical Biology Team

Promotion of life science and drug discovery by world’s first innovative chemistries.

* Due to the reorganization starting as new centers in April 2018, this laboratory is now belong to the Center for Biosystems Dynamics Research. As for the latest information, please see the following URL below.
> The webpage of Laboratory for Chemical Biology, Center for Biosystems Dynamics Research

Team Leader
Takamitsu Hosoya Ph.D.

6-7-3 Minatojima-minamimachi, Chuo-ku Kobe, Hyogo, 650-0047, Japan
Tel: +81-(0)78-304-7130

>>> Lab Site

Research Area

In order to promote human live science and drug discovery, it is necessary to develop new methods and tools based on innovative chemistries. Through the researches under collaboration with a number of scientists of different disciplines, we are trying to develop useful PET probes for in vivo imaging of target molecules, nobel strategies for efficient PET probe synthesis, chemical tools and methods that facilitate chemical biology researches, and efficient synthetic methods of valuable compounds.

Main Publications List

Rhodium-Catalyzed ipso-Borylation of Alkylthioarenes via C–S Bond Cleavage

Uetake Y, Niwa T, Hosoya T.
Org Lett, 18(11), 2758-2761 (2016).

Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C-F Bond Functionalizations

Niwa T, Ochiai H, Watanabe Y, Hosoya T
J Am Chem Soc, 137(45), 14313-14318 (2015).

Pd-0-Mediated Rapid Cross-Coupling Reactions, the Rapid C-[C-11]Methylations, Revolutionarily Advancing the Syntheses of Short-Lived PET Molecular Probes

Suzuki M, Doi H, Koyama H, Zhang Z, Hosoya T, Onoe H, Watanabe Y.
Chem Rec, 14(3), 516-541 (2014).

[¹¹C]Cetrozole: an Improved C-[¹¹C]Methylated PET Probe for Aromatase Imaging in the Brain.

Takahashi K, Hosoya T, Onoe K, Doi H, Nagata H, Hiramatsu T, Li XL, Watanabe Y, Wada Y, Takashima T, Suzuki M, Onoe H, Watanabe Y.
J Nucl Med, 55(5), 852-857 (2014).

Investigation of the Effect of Active Efflux at the Blood-Brain Barrier on the Distribution of Nonsteroidal Aromatase Inhibitors in the Central Nervous System

Miyajima, M; Kusuhara, H; Takahashi, K; Takashima, T; Hosoya, T; Watanabe, Y; Sugiyama, Y
J Pharm Sci, 102(9), 3309-3319 (2013).

Pd⁰-mediated rapid coupling of methyl iodide with excess amounts of benzyl- and cinnamylboronic acid esters: efficient method for incorporation of positron-emitting ¹¹C radionuclide into organic frameworks by coupling between two sp³-hybridized carbons

Koyama, H., Zhang, Z. Ijuin, R., Siqin, Son, J., Hatta, Y., Ohta, M., Wakao, M., Hosoya, T., Doi H., and Suzuki, M.
RSC Adv, 3(24), 9391-9401 (2013).

PET of aromatase in gastric parietal cells using ¹¹C-vorozole.

Ozawa M, Takahashi K, Akazawa KH, Takashima T, Nagata H, Doi H, Hosoya T, Wada Y, Cui Y, Kataoka Y, Watanabe Y.
J Nucl Med, 52(12), 1964-1969 (2011).

Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids: PET study with [¹¹C]vorozole.

Takahashi K, Onoe K, Doi H, Nagata H, Yamagishi G, Hosoya T, Tamura Y, Wada Y, Yamanaka H, Yokoyama C, Mizuma H, Takashima T, Bergström M, Onoe H, Långström B, Watanabe Y.
Neuroreport, 22(7), 326-330 (2011).

Practical synthesis of precursor of [N-methyl-¹¹C]vorozole, an efficient PET tracer targeting aromatase in the brain.

Takahashi K, Yamagishi G, Hiramatsu T, Hosoya A, Onoe K, Doi H, Nagata H, Wada Y, Onoe H, Watanabe Y, Hosoya T.
Bioorg Med Chem, 19(4), 1464-1470 (2011).

Functional role of neuroendocrine-specific protein-like 1 in membrane translocation of GLUT4.

Ikemoto T, Hosoya T, Takata K, Aoyama H, Hiramatsu T, Onoe H, Suzuki M, Endo M.
Diabetes, 58(12), 2802-2812 (2009).

Palladium(0)-mediated rapid methylation and fluoromethylation on carbon frameworks by reacting methyl and fluoromethyl iodide with aryl and alkenyl boronic acid esters: useful for the synthesis of [¹¹C]CH(3)--C- and [¹⁸F]FCH2--C-Containing PET tracers (PET=positron emission tomography).

Doi H, Ban I, Nonoyama A, Sumi K, Kuang C, Hosoya T, Tsukada H, Suzuki M.
Chemistry, 15(16), 4165-4171 (2009).

>>>All Publications

Member *concurrent

Takamitsu Hosoya
Team Leader

>>>Curriculum vitae
Takashi Niwa
Deputy Team Leader

>>>Curriculum vitae
Hiroo Koyama
Senior Scientist^*
Zhouen Zhang
Research Scientist

>>>Curriculum vitae
Yuto Sumida
Research Scientist

>>>Curriculum vitae
Motoyuki Isoda
Postdoctoral Researcher

>>>Curriculum vitae
Tomoe Sumida
Technical Staff I

>>>Curriculum vitae

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