Labs & Technologies

Advanced Solid-State NMR Unit

Development and application of novel solid-state NMR methods to piering the structures and dynamics in the atomic level

* Due to the reorganization starting as new centers in April 2018, this laboratory is now belong to the RIKEN Baton Zone Program. As for the latest information, please see the following URL below.
> The webpage of Nano-crystallography unit, the RIKEN Baton Zone Program

Unit Leader
Yusuke Nishiyama Ph.D.

W121, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045

Research Area

We develop novel solid-state NMR methods to understand the molecular structures and dynamics in the atomic level and apply these techniques to various materials. We have cutting edge solid-state NMR equipment including ultrafast MAS of 120 kHz and high magnetic fields up to 900 MHz. Our interest includes biomolecules, proteins, peptides, catalysis, pharmaceutical compounds, organic-inorganic hybrid materials, natural minerals etc.

Main Publications List

Ultra-fast Magic Angle Spinning: Benefits for the Acquisition of Ultra-wideline NMR Spectra of Heavy Spin-1/2 Nuclei.

P_ppler AC, Demers JP, Malon M, Singh AP, Roesky HW, Nishiyama Y, Lange A
Chemphyschem, 17(6), 812-816 (2016).

Two-dimensional proton-detected ³⁵Cl/¹H correlation solid-state NMR experiment under fast magic angle sample spinning: Application to pharmaceutical compounds

Manoj Kumar Pandey, Hiroshi Kato, Yuji Ishii, Yusuke Nishiyama
Phys Chem Chem Phys,(18), 6209-6216 (2016).

1020 MHz Single-Channel Proton Fast Magic Angle Spinning Solid-State NMR Spectroscopy.

Pandey MK, Zhang R, Hashi K, Ohki S, Nishijima G, Matsumoto S, Noguchi T, Deguchi K, Goto A, Shimizu T, Maeda H, Takahashi M, Yanagisawa Y, Yamazaki T, Iguchi S, Tanaka R, Nemoto T, Miyamoto T, Suematsu H, Saito K, Miki T, Ramamoorthy A, Nishiyama Y.
J Magn Reson, 261, 1–5 (2015).

High-resolution NMR-based metabolic detection of microgram biopsies using a 1 mm HRμMAS probe.

Nishiyama Y, Endo Y, Nemoto T, Bouzier-Sore AK, Wong A.
Analyst, 140(24), 8097-8100 (2015).

The use of a selective saturation pulse to suppress t₁ noise in two-dimensional ¹H fast magic angle spinning solid-state NMR spectroscopy.

Robertson AJ, Pandey MK, Marsh A, Nishiyama Y, Brown SP.
J Magn Reson., 260, 89-97 (2015).

Determination of NH proton chemical shift anisotropy with ¹⁴N–¹H heteronuclear decoupling using ultrafast magic angle spinning solid-state NMR

Pandey MK, Nishiyama Y.
J Magn Reson., 261, 133-140 (2015).

Proton-detected 3D ¹H/¹³C/¹H correlation experiment for structural analysis in rigid solids under ultrafast-MAS above 60 kHz.

Zhang R, Nishiyama Y, Ramamoorthy A.
J Chem Phys., 143(16), 164201 (2015).

Evolution of CPMAS under fast magic-angle-spinning at 100kHz and beyond.

Wickramasinghe A, Wang S, Matsuda I, Nishiyama Y, Nemoto T, Endo Y, Ishii Y.
Solid State Nucl Magn Reson., S0926-2040(15), 30025-4 (2015).

Nano-mole scale sequential signal assignment by ¹H-detected protein solid-state NMR

Wang S, Parthasarathy S, Xiao Y, Nishiyama Y, Long F, Matsuda I, Endo Y, Nemoto T, Yamauchi K, Asakura T, Takeda M, Terauchi T, Kainoshogi M, Ishii Y.
Chem. Commun., 51, 15055-15058 (2015).

Proton-detected 3D ¹⁴N/¹⁴N/¹H isotropic shift correlation experiment mediated through ¹H–¹H RFDR mixing on a natural abundant sample under ultrafast MAS

Pandey MK, Nishiyama Y
J Magn Reson., 258, 96-101 (2015).

A Novel High-Resolution and Sensitivity-Enhanced Three-Dimensional Solid-State NMR Experiment Under Ultrafast Magic Angle Spinning Conditions.

Zhang R, Pandey MK, Nishiyama Y, Ramamoorthy A.
Sci Rep., 5, 11810 (2015).

Accurate NMR determination of C–H or N–H distances for unlabeled molecules

Nishiyama Y, Malon M, Potrzebowski MJ, Paluch P, Amoureux JP.
Solid State Nucl Magn Reson., S0926-2040(15), 30005-9 (2015).

>>>ALL Publications

Member *concurrent

Yusuke Nishiyama
Unit Leader
Miwa Wakabayashi
Technical Scientist
Tuan Nghia Duong
Research Associate
Michal Malon
Visiting Scientist
Manoj Kumar Pandey
Research Scientist
Youlee Hong
Visiting Researcher
Yuki Endo
Research Fellow
Takahiro Nemoto
Research Fellow

News

News 2017/03/07
Coulee Hong and Nghia Tuan Duong awarded for poster prize in NMR

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Labs & Technologies

Advanced Solid-State NMR Unit

Research Area

Main Publications List

Ultra-fast Magic Angle Spinning: Benefits for the Acquisition of Ultra-wideline NMR Spectra of Heavy Spin-1/2 Nuclei.

Two-dimensional proton-detected ³⁵Cl/¹H correlation solid-state NMR experiment under fast magic angle sample spinning: Application to pharmaceutical compounds

1020 MHz Single-Channel Proton Fast Magic Angle Spinning Solid-State NMR Spectroscopy.

High-resolution NMR-based metabolic detection of microgram biopsies using a 1 mm HRμMAS probe.

The use of a selective saturation pulse to suppress t₁ noise in two-dimensional ¹H fast magic angle spinning solid-state NMR spectroscopy.

Determination of NH proton chemical shift anisotropy with ¹⁴N–¹H heteronuclear decoupling using ultrafast magic angle spinning solid-state NMR

Proton-detected 3D ¹H/¹³C/¹H correlation experiment for structural analysis in rigid solids under ultrafast-MAS above 60 kHz.

Evolution of CPMAS under fast magic-angle-spinning at 100kHz and beyond.

Nano-mole scale sequential signal assignment by ¹H-detected protein solid-state NMR

Proton-detected 3D ¹⁴N/¹⁴N/¹H isotropic shift correlation experiment mediated through ¹H–¹H RFDR mixing on a natural abundant sample under ultrafast MAS

A Novel High-Resolution and Sensitivity-Enhanced Three-Dimensional Solid-State NMR Experiment Under Ultrafast Magic Angle Spinning Conditions.

Accurate NMR determination of C–H or N–H distances for unlabeled molecules

Member *concurrent

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