This unit aims to engineer functional bio-macromolecules applicable to medical and basic biological researches, by integrating technologies in synthetic and structural biology including 1) in vitro reconstruction of target protein complexes, 2) in vitro evolution of peptide/RNA, 3) protein X-ray crystallography, and 4) structure based protein/drug engineering. Delivery systems for the engineered molecules will be also developed in collaboration with the Molecular Network Contraol Imaging Unit.