RIKEN Center for Life Science Technologies


  • Research

    Latest publications from CLST.
  • News

    Awards, agreements, and other news.
  • Events

    Upcoming and past events including seminars, symposiums, open days.

For Public

To let you know about our research, this area contains 4 types of information about CLST; “Article”, “Videos”, “Event” and “Study”.
At “Article”, you can read articles on interviews and lectures, and you can enjoy the videos about CLST at “Videos”. If you want to meet and talk directly with the researcher, “Visit” give you some information of such events. You can find more difficult contents to know about our research deeply at “Study”.
  • Article
  • Event
  • Videos
  • Study


  • [NEW][Sep 29, 2016] The 3rd RIKEN CLST Karolinska Institutet SciLifeLab Joint Symposium: Frontiers in Life Science Technologies - Decoding Health and Disease

    A joint international symposium: The 3rd RIKEN CLST Karolinska Institutet SciLifeLab Joint Symposium will be held on 29th September.
  • World record of a magnetic field strength for fully-superconducting magnets

    The research team of RIKEN, NIMS, Kobe Steel and JEOL RESONANCE have successfully developed a 27.6 T NMR magnet, establishing the world’s highest magnetic field in high resolution NMR superconducting magnets (as of 01/Apr/2016).
  • How Acyclic retinoid prevents the recurrence of Liver cancer

    A research group lead by a Special Unit Leader, Soichi Kojima, of RIKEN Center for Life Science Technologies, reported a molecular basis for nuclear-cytoplasmic transport of transglutaminase 2 and a role of acyclic retinoid in it.
  • Yuko Kiyosue awarded for best paper in Science

    Yuko Kiyosue, who leads the Cellular Dynamics Analysis Unit at the RIKEN Center for Life Science Technologies (CLST) was one of the authors of a paper awarded the AAAS Newcomb Cleveland Prize, which is given out every year for the best paper published in Science that year.
  • Computational tool for designing internal probes with matching primer sets for real-time PCR experiments and melting curve analysis of genetic variations

    Edesign, an efficient computational tool for designing internal probes with matching primer sets for real-time PCR experiments and melting curve analysis of genetic variations, has been developed by researchers at RIKEN and the Japanese firm K.K.DNAFORM.
  • Development of Novel PET probe for detecting bone metastatic tumor with thymidine analogs

    Bio-Function Imaging Team has tried to evaluate whether that 11C-labeled AZT and d4T, which are known as thymidine analogs and anti-HIV drugs, are useful for PET tumor imaging and it found that the [11C]AZT were remarkably accumulated in tumor.
  • [Feb.8-12] Karolinska Institutet - RIKEN joint doctoral course 2016 "Non-coding RNA as epigenetic regulators: methods, omics technologies and applications in medicine"

    A joint international doctoral course on the subject Non-coding RNA as epigenetic regulators: methods, omics technologies and applications in medicine between the RIKEN Yokohama institute Center for Life Science Technologies (CLST) and Karolinska Institutet Department of Cell and Molecular Biology (Sweden) will be held from February 8th to 12th at the Karolinska Institutet in Stockholm.
  • Meet a new model animal, the ocelot gecko

    A search is thus on for useful model reptiles to use in developmental biology. As part of this quest, researchers from the RIKEN Center for Life Science Technologies in Kobe focused their sights on the ocelot gecko (Paroedura picta), an adorable lizard from Madagascar, and produced an inventory of functioning genes in embryos of this species, with the goal of pinpointing the genes involved in its development.
  • RIKEN CLST – Karolinska Institutet – SciLifeLab Joint Symposium on Structural Biology was held in Yokohama.

    On November 12, the second RIKEN CLST – Karolinska Institutet – SciLifeLab Joint Symposium was held at Yokohama campus of RIKEN. This is the second event between RIKEN CLST and Sweden’s two major institutes, Karolinska Institutet and Science for Life Laboratory (SciLifeLab).
  • A treasure trove of new cancer biomarkers

    Biomarkers, which allow diseases to be diagnosed and staged based on relatively non-invasive blood tests, have been identified for several types of cancers, but for most cancers remain elusive. Now, research conducted at the RIKEN Center for Life Science Technologies (CLST) in Japan and the Harry Perkins Institute of Medical Research in Australia has identified a large number of genes that are upregulated in many different types of cancer, opening the door for developing biomarker tests that could be used to detect cancers early, allowing for prompt treatment.
  • Retroviral RNA may play a part in liver cancer

    An international group led by RIKEN in Japan and INSERM in France have found that retroviral long-terminal-repeat (LTR) promoters—a type of repetitive element that are widely distributed in the human genome—are highly activated in hepatocellular carcinomas, the most common type of liver cancer. Intriguingly, these areas—which are particularly activated in HCCs associated with viral hepatitis, are not normally activated in the liver but are in reproductive tissues such as testis and placenta. The study, published in Genome Research, suggests that the activation of LTR promoters might contribute to the development of cancer in the liver.
  • Forcing a molecular light switch

    A chance observation led to RIKEN researchers discovering an organic compound whose fluorescence wavelength varies greatly when it is subjected to a mechanical force1. This property makes it an attractive material for various applications in security as well as medical imaging and therapy.
  • Tracing the spread of vitamin B1

    RIKEN was, from its earliest days, a pioneer in vitamin research. A century later, RIKEN is still on the leading edge of vitamin research. In May, researchers from the RIKEN Center for Life Science Technologies (CLST) announced the development of a technique to "tag" vitamin B1 and a thiamine analogue, fursultiamine, with a short-lived radioisotope of carbon, 11C (which has a half-life of 20.4 min), allowing the use of PET imaging to determine how the vitamin spreads through the body following injection.
  • A dictionary of the language of cells

    In their struggle to survive and prosper, multicellular organisms rely on a complex network of communication between cells, which in humans are believed to number about 40 trillion. Now, in a study published in Nature Communications, a research group led by scientists from the RIKEN Center for Life Science Technologies (CLST) has published an overall map of how the cells in the human body communicate by systematically analyzing the relationship between ligands—substances such as insulin and interferon that embody messages between cells, and receptors—the proteins on cell surfaces that receive these messages when bound by the ligands.
  • Engineering the world’s smallest nanocrystal

    Now, in research published in Angewandte Chemie International Edition, scientists from the group of Kam Zhang at the RIKEN Center for Life Science Technologies (CLST) and the group of Jeremy Tame at Yokohama City University in Japan have used an artificially designed protein to create a cadmium chloride nanocrystal—the smallest crystal reported so far, made up of just 19 atoms—sandwiched between two copies of the protein.
  • World’s Highest Magnetic Field* (1,020MHz) NMR developed

    The research team of NIMS, RIKEN, Kobe Steel and JEOL RESONANCE successfully developed the NMR system equipped with world’s highest magnetic field, 1,020 MHz, supported by the JST-SENTAN program “Development of Systems and Technology for Advanced Measurement and Analysis”. This research result was published in Journal of Magnetic Resonance on 15 May 2015 (Kenjiro Hashi, Shinobu Ohki, Shinji Matsumoto, Gen Nishijima, Atsushi Goto, Kenzo Deguchi, Kazuhiko Yamada, Takashi Noguchi, Shuji Sakai, Masato Takahashi, Yoshinori Yanagisawa, Seiya Iguchi, Toshio Yamazaki, Hideaki Maeda, Ryoji Tanaka, Takahiro Nemoto, Hiroto Suematsu, Takashi Miki, Kazuyoshi Saito and Tadashi Shimizu, Title:”Achievement of 1,020 MHz NMR”, DOI:10.1016/j.jmr.2015.04.009).
  • Seeking a Unit Leader [DDI-1501]

    The Drug Discovery Imaging Platform Unit is advancing in vivo pharmacokinetic research of marmosets (monkeys), mice and humans by utilizing molecular imaging technology focused on positron emission tomography (PET). Labeling technologies for molecular imaging probes guarantee in vivo observation time and improve tracing after metabolic breakdown. Also, with a view to clinical studies of microdoses, we aim to build new drug discovery processes, developing labeling and probes for drug candidate compounds, as well as utilizing mice-to-human streamlined molecular imaging techniques.
  • Seeking a Team Leader [GIAT-1501]

    The Genome Information Analysis Team studies transcriptional networks and develops innovative analysis technologies based on next generation sequencing data. Currently there are several bioinformaticians and a wet technician in the team and research projects include cancer biomarker discovery, transcriptional network models, time-series analysis, development of new bioinformatics tools such as the ZENBU Genome Browser and the over-arching bioinformatics analysis for the FANTOM projects. There is potential for the new leader to build a research portfolio based on analysis of large scale Next Generation Sequencing (NGS) data, in particular coupled to new technologies, which we develop in the Division, to broadly understand biological function.
  • iPS and embryonic stem cells: not quite the same

    In research recently published in Cell Cycle, a group of scientists led by Piero Carninci of the RIKEN Center for Life Science Technologies analyzed the genes that are transcribed in the nuclei of embryonic stem cells and iPS cells—a type of cell that is reprogrammed from normal somatic cells with the intention to have them act like stem cells—and discovered that there are significant differences between the two.
  • Remapping the damaged brain

    Scientists at CLST, along with researchers from the AIST have identified a time-dependent interplay between two brain regions that contributes to the recovery of motor function after focal brain damage, such as a stroke. Published in the Journal of Neuroscience, the research shows that when motor functions are remapped through rehabilitative training, brain regions relatively distant from a lesion are recruited during the initial stages and functional connections with regions near the lesion are strengthened during the latter stages.


For Public


RIKEN YOKOHAMA campus Open Day will be held on Sep 10 !