We plan to establish a structural analysis technology platform to contribute to "life innovation" such as drug discovery and medical treatment as well as develop methods for the sample preparation and crystallization of challenging proteins including membrane proteins that have been difficult in its analysis. The high-resolution structural information of proteins related to diseases shall increasingly become important for drug development leading to future individualized medicine such as a molecular target drug. Especially, we will perform structural analysis mainly for proteins related to immune system diseases and kinases associated with cancer/leukemia. The 3D-structural information of these target proteins will be used for in silico screening of chemical compounds. Further analysis of the complex of the target protein with candidate compounds will provide valuable information for drug discovery.